CASP1 and Alzheimer disease: Following treadmill exercise, AD-EXE mice showed significant reduction in protein levels of NLRP3 (p < 0.0001, Figure 2F), ASC (p < 0.0001, Figure 2G), caspase-1 p20 (p < 0.0001, Figure 2H), and IL-1β (p = 0.0003, Figure 2I) compared with AD-SED mice.