CASP1 and Alzheimer disease: Results showed that AD-SED mice displayed increased activation of NLRP3 inflammasome pathway compared with WT-SED mice, with significantly increased protein levels of NLRP3 (p < 0.0001, Figure 2F), ASC (p < 0.0001, Figure 2G), caspase-1 p20 (p < 0.0001, Figure 2H), and IL-1β (p < 0.0001, Figure 2I) in the hippocampus.