This can include measurements of circulating markers of endothelial dysfunction or injury that have been correlated with kidney outcomes such as ET-1, asymmetric dimethylarginine (ADMA), soluble vascular or intracellular adhesion molecules (VCAM-1 or ICAM-1), von Willebrand factor (vWF), and high-sensitivity C-reactive protein (hs-CRP) (30). This evidence concerns the gene VWF and endothelial dysfunction.