However, preliminary experimental results by our group have shown that GPS5 infection in mice caused inflammation in the lungs and liver of mice, along with significantly increased transcription levels of TNF‐α, IL‐1β, and IL‐6 in these tissues (data not shown), so mice may not be the optimal but can still be used as the experimental model to evaluate the protective efficacy of the vaccine to a certain extent. The gene discussed is IL6; the disease is infection.