Leukotrienes have been considered key contributors to hypertension, probably due to their direct regulatory role in the circulatory system or indirectly via the renin-angiotensin system (Smedegard et al., 1982; Stanke-Labesque et al., 2001; Stanke-Labesque et al., 2002; Stenmark et al., 1983). This evidence concerns the gene REN and hypertensive disorder.