A recent study revealed that endothelial SWELL1 plays a crucial role in mediating endothelial migration and alignment in response to shear-flow stimulation, while endothelial-specific deletion of Swell1 leads to hypertension in response to chronic angiotensin II infusion and constricted retinal vessels in a type 2 diabetes mellitus model (Alghanem et al., 2021). The gene discussed is LRRC8A; the disease is hypertensive disorder.