Given the findings in adult mice showing that loss of endothelial Swell1/VRAC leads to exacerbated hypertension and retinal hypoperfusion due to vessel constriction (Alghanem et al., 2021), our study in zebrafish embryos underscores the importance of Swell1/VRAC function across developmental stages. This evidence concerns the gene LRRC8A and hypertensive disorder.