Future research should focus on the following directions: First, apply single-cell epigenomics technologies to decipher the precise role of CARM1 in muscle stem cell fate determination; second, develop CARM1 substrate-specific inhibitors to explore their potential for targeted intervention in diseases such as muscular atrophy and diabetic myopathy; Third, integrating a gender medicine perspective to investigate the differential mechanisms of CARM1-mediated epigenetic regulation in skeletal muscle adaptation across genders. Here, CARM1 is linked to muscular atrophy.