In different tumor types, its role can be even opposite: in some cancers, METTL5 acts as an oncogene by enhancing the translation of pro-tumor transcription factors, whereas in other tumors, its loss impairs cell survival, reflecting a role in maintaining basal translational homeostasis (Dai et al., 2023; Huang et al., 2022). This evidence concerns the gene METTL5 and cancer.