NFKB1 and Alzheimer disease: Moreover, the C-type lectin receptor Clec7a (Dectin-1), another receptor implicated in AD, binds Aβ and mediates pro-inflammatory responses via Syk/NF-κB signaling (Zhao et al., 2023), a pathway reported to be influenced by Gal3 in other cell types (Chen et al., 2022; Esteban et al., 2011).