LGALS3 and Alzheimer disease: Our group has previously demonstrated a critical role for microglial Gal3 in AD interacting with the microglial receptor TREM2 (Boza-Serrano et al., 2019) and TLR4 (Burguillos et al., 2015), as well as being an important molecule in protective immune priming in AD (Yang et al., 2023).