For instance, we have demonstrated that Gal3 can be secreted by microglia under certain circumstances, playing roles such as opsonization of damaged neurons in PD models and further phagocytosis (Garcia-Revilla et al., 2024), but whether only extracellular or intracellular Gal3 plays a role in phagocytosis is not known. This evidence concerns the gene LGALS3 and Parkinson disease.