Our group has previously demonstrated a critical role for microglial Gal3 in AD interacting with the microglial receptor TREM2 (Boza-Serrano et al., 2019) and TLR4 (Burguillos et al., 2015), as well as being an important molecule in protective immune priming in AD (Yang et al., 2023). This evidence concerns the gene TLR4 and Alzheimer disease.