Since microglial Gal3 has been implicated in multiple aspects of AD pathogenesis (Garcia-Revilla et al., 2022; Boza-Serrano et al., 2019; Tao et al., 2020; Boza-Serrano et al., 2022), we next investigated its relationship with microglial receptors that play central roles in microglial phenotype regulation and AD progression: TREM2, TLR4, and Clec7a (Hansen et al., 2018; Valiukas et al., 2025; Krasemann et al., 2017; Keren-Shaul et al., 2017; Huang et al., 2021; Miron et al., 2018; Roy et al., 2020). This evidence concerns the gene TLR4 and Alzheimer disease.