Thus, the pathological features of neurodevelopmental disorders such as autism and schizophrenia can be mimicked in rodents, for instance by perinatal immune activation (reproducing a microbial infection during development) or by the deletion of the DISC1 gene (linked to schizophrenia) or FMR1 gene (Fragile X syndrome) or the 22q11.2 locus (DiGeorge syndrome). Here, DISC1 is linked to schizophrenia.