Zhang et al. [93] demonstrated that engineered exosomes efficiently delivered miR‐29b to activated HSCs, suppressed their activation by downregulating fibrotic markers, such as α‐SMA and COL1A1, and significantly reduced collagen deposition and fibrosis in liver fibrosis models by inhibiting the TGF‐β/Smad signaling pathway. The gene discussed is ACTA1; the disease is Hepatic fibrosis.