For instance, asiatic acid has been shown to attenuate CCl4‐induced liver fibrosis in rats and suppress TGF‐β1‐stimulated activation of HSCs in vitro by upregulating Smad7, thereby blocking Smad2/3 phosphorylation, reducing α‐SMA and collagen matrix expression [97]. Here, SMAD7 is linked to Hepatic fibrosis.