ANA: Antinuclear antibody; anti-dsDNA: Anti-double-stranded DNA; anti-CCP: Anti-cyclic citrullinated peptide antibody; anti-RNP: Anti-ribonucleoprotein antibody; AMA: Anti-mitochondrial antibody; anti-Scl-70: Anti-scleroderma-70 antibodies; SmD1: Smith antibodies; anti-SS–A/Ro 60 KD: Sjogren anti-SS-A; anti-SS–A/Ro 52 KD: Sjogren anti-SS-B; anti-U1-snRNP: U1 small nuclear ribonucleoprotein particle. The gene discussed is SNRPD1; the disease is scleroderma.