The search used Boolean operators to combine key concepts, including terms such as “myocardial ischemia-reperfusion injury” OR “MIRI”, paired with “pyroptosis” OR “inflammasome” OR “NLRP3” OR “GSDMD”, and further linked to therapeutic terms such as “therapy”, “treatment”, “intervention”, or “cardioprotection”. The gene discussed is NLRP3; the disease is myocardial ischemia.