RCT: randomized controlled trial; PASI: Psoriasis Area and Severity Index; PGA: Physician Global Assessment; AE: adverse event; HC: hydrocortisone; VAS: Visual Analogue Scale; DLQI: Dermatology Life Quality Index; PsA: psoriatic arthritis; CFU: colony-forming unit; PSS: Psoriasis Symptom Scale; BDI: Beck Depression Inventory; hs-CRP: high-sensitivity C-reactive protein; IL: interleukin; MDA: malondialdehyde; TAC: total antioxidant capacity; QoL: quality of life; SOC: standard of care; BSA: body surface area; ns: not significant; ITT: intention-to-treat analysis; PP: per-protocol analysis. Here, CRP is linked to major depressive disorder.