HE was initially described in 1966 as an acute or subacute encephalopathy or myelopathy associated with high serum levels of antithyroid antibodies (anti-thyroglobulin antibodies (anti-TG) and antithyroid peroxidase antibodies (anti-TPO)), normal or abnormal thyroid function, and good response to corticosteroids [1]. The gene discussed is TG; the disease is hereditary elliptocytosis.