Our previous studies have indicated that BPLP could ameliorate colitis and CAC by remodeling the gut microbiome, including Lachnospiraceae, Rikenellaceae, and Prevotella. These findings suggested that the microbiota might mediate the regulation of amino acid metabolism and colitis alleviation in colitis mice supplemented with BPLP, whose mechanism needs more studies to explore. This evidence concerns the gene OPRPN and colitis.