Epigallocatechin gallate (EGCG) activates AMP-activated protein kinase (AMPK), promoting fat oxidation and improving insulin sensitivity. It induces apoptosis in cancer cells, inhibits angiogenesis (via VEGF suppression), and reduces lipid peroxidation, acting as a potent antioxidant. Also, it enhances endothelial function; activates SIRT1. The gene discussed is SIRT1; the disease is cancer.