FAK inhibition reduces desmoplasia and reprograms cancer-associated fibroblast (CAF)-rich stroma, increases CD8+ cytotoxic T-cell infiltration, and can render tumors responsive to programmed cell death protein 1 (PD-1) blockade (shown in pancreatic ductal adenocarcinoma) (97, 99, 100). Here, PTK2 is linked to cancer.