In our cohort of 100 patients with locally advanced HNSCC, high LAT1 expression was associated with significantly worse overall survival, and was enriched in transcriptomic subtypes previously linked to biologically aggressive and radioresistant behavior, specifically, the mesenchymal (Cluster 2) and hypoxic (Cluster 3) subtypes. This evidence concerns the gene SLC7A5 and head and neck squamous cell carcinoma.