Pooled analyses indicated higher concentrations of tumor necrosis factor-α (TNF-α: SMD = 8.96, 95% CI [4.96, 12.95], p < 0.0001), interleukin-2 (IL-2: SMD = 4.54, 95% CI [1.57, 7.51], p = 0.003), interferon-γ (IFN-γ: SMD = 4.29, 95% CI [1.80, 6.78], p = 0.0007), interleukin-12 (IL-12: SMD = 3.66, 95% CI [2.53, 4.80], p < 0.00001), and interleukin-6 (IL-6: SMD = 11.07, 95% CI [1.44, 20.70], p = 0.02) in the APS combination groups. Here, IL6 is linked to autoimmune polyendocrinopathy.