RBX1 and Familial prostate cancer: Supporting the relevance of this mechanism, TCGA prostate cancer data show an inverse correlation between RBX1 and POLR2A expression (R = −0.45), suggesting that the loss of POLR2A in cells with deletion of the 17p chromosomal region may be functionally compensated by RBX1 upregulation (Li et al., 2018).