Supporting the relevance of this mechanism, TCGA prostate cancer data show an inverse correlation between RBX1 and POLR2A expression (R = −0.45), suggesting that the loss of POLR2A in cells with deletion of the 17p chromosomal region may be functionally compensated by RBX1 upregulation (Li et al., 2018). Here, POLR2A is linked to Familial prostate cancer.