POLR2A and neoplasm: Global transcriptomic profiling showed that POLR2A knockout markedly suppressed oncogenic and antiapoptotic genes, including MYC, RUNX2, MEIS1, CDC25A, and BCL-2, leading to impaired proliferation and a significant reduction in tumor cell populations at 7 and 14 days after implantation in vivo (Yu et al., 2019).