Hyperglycemia significantly upregulates NLRP3 and pro-IL-1β expression via the NF-κB pathway, whereas mitochondrial ROS accumulation and K+ efflux trigger inflammasome assembly, activating caspase-1 and promoting IL-1β/IL-18 maturation and release (Ram et al., 2020). The gene discussed is IL1B; the disease is Hyperglycemia.