Recent studies have shown that chronic inflammation induced by the cGAS‒STING pathway drives the development of various diseases,30 such as systemic lupus erythematosus,35 rheumatoid arthritis,36 atherosclerosis,37 myocardial infarction,38 diabetes,39 obesity,40 Alzheimer’s disease,41 Parkinson’s disease,10 liver cirrhosis,42 and sepsis.43 Here, CGAS is linked to obesity due to melanocortin 4 receptor deficiency.