KICS was first defined by Polizzotto et al. [23] and includes (1) clinical manifestations: (a) symptoms (fever, fatigue, and edema), (b) laboratory abnormalities (anemia, thrombocytopenia, hypoalbuminemia, and hyponatremia), and (c) imaging findings (lymphadenopathy, hepatosplenomegaly, and effusions); (2) evidence of systemic inflammation: elevated CRP (≥ 3 g/dL); (3) evidence of KSHV viral activity; and (4) the absence of evidence of MCD on histopathologic review of tissue from lymph node biopsy. Here, CRP is linked to anemia (phenotype).