,9 Of note, few studies also reported about distinct miRNA profiles in individuals with chronic liver diseases carrying the PNPLA3 p.I148M risk allele.10, 11, 12 Here we demonstrate that miR-335-5p performs very well as a predictor of HCC in receiver operating characteristic (ROC) curve analyses. Here, PNPLA3 is linked to hepatocellular carcinoma.