PNPLA3 and hepatocellular carcinoma: In particular, this miRNA can differentiate individuals with simple steatosis from healthy ones, it also emerged as the best predictor for “MASLD complication” vs simple steatosis; 2) miR-335-5p is present at lower levels in patients with HCC compared to healthy controls; and 3) the PNPLA3 p.I148M risk genotype does not seem to strongly affect serum levels of the 10 miRNAs.