AQP7 and tongue cancer: Research has shown that AQP7 shows overexpression in thyroid cancer while serving as a potential therapeutic target in breast cancer but no studies exist about its function in HNSCC.104, 105, 106 Additional research into AQP7 function is necessary to establish its potential as a biomarker or therapeutic target because tongue cancer shows distinct patterns between HPV-positive and HPV-negative cases.107