It is importantto note that the inhibitor VER-155008 has been characterized extensivelyfor human Hsp70/Hsc70 isoforms, but its efficacy or binding profileacross nonhuman homologues remains poorly documented in the literature.Our study also provides insights into the conformational changes inducedby inhibitor binding over time, which are crucial for understandingthe binding mechanism of VER-155008 against Hsp70, which could beuseful to create more selective inhibitors that effectively targetHsp70s cancer-related functions while minimizing effects on Hsc70. This evidence concerns the gene HSPA8 and cancer.