The high structural similarity betweenthese two proteins makes developing selective inhibitors challenging.Our study demonstrates that VER-155008 interacts with the residuesSer275, Lys271, and Glu268 located at the nucleotide binding pocketof both proteins, and it has a pronounced impact on the conformationalstability of Hsc70, exceeding its effect on Hsp70, an important moleculartarget in cancer. This evidence concerns the gene HSPA8 and cancer.