Here, we investigated the autonomouseffects of the PKC-δ C2 domain in two breast cancer cell lines,representing hormone-dependent and triple-negative breast cancer.A myc-tagged PKC-δ C2 domain (myc-δC2) was stably overexpressedin MCF-7 and MDA-MB-468 cells, and its effects on cell viability,apoptosis, and proliferation were assessed. Here, PRKCD is linked to triple-negative breast carcinoma.