PRKCD and breast cancer: Preclinical studies indicate context-dependentroles of PKC-δin BC.,−, , In MCF-7 (luminal A model), PKC-δ knockdown or inhibitionwith Rottlerin reduced proliferation,, whereas overexpressionincreased apoptosis, seemingly engaging pro-apoptotic pathways. In triple-negative MDA-MB-468, PKC-δ wasphosphorylated in a complex pattern unrelated to mezerein-inducedgrowth inhibition, yet its overexpressionsensitized these SMAC-mimetic-resistant cells to SMAC mimetics.