Overall, the results suggest that susceptibility to SE is lower in tau−/− mice, consistent with results of previous studies showing reduced seizure activity in mice lacking tau expression in models of genetic epilepsies and lower seizure susceptibility to chemo-convulsant evoked seizures (Roberson et al., 2007; DeVos et al., 2013; Gheyara et al., 2014; Li et al., 2014; Putra et al., 2020). Here, MAPT is linked to epilepsy.