Another study found that human antimicrobial peptide LL-37 promotes chloride intracellular channel protein 1 (CLIC1) activation in mouse microglia, triggering neuroinflammation, excitotoxicity and Alzheimer’s disease-related neuropathological changes like amyloid and tau pathology, neurodegeneration and cognitive impairment [12]. This evidence concerns the gene CLIC1 and early-onset autosomal dominant Alzheimer disease.