PCSK1N and major depressive disorder: However, SAAS (OR for moderate = 1.14, p = 0.450; OR for severe = 1.36, p = 0.236) and HADS (OR for mild = 1.45, p = 0.290; OR for moderate = 1.32, p = 0.458; OR for severe = 1.87, p = 0.268) were not independently associated with acne, suggesting that social appearance anxiety and general anxiety/depression symptoms do not contribute significantly beyond demographic and lifestyle factors.