Figure 1A depicts the AR activity across all TCGA tumors (10,340 samples in 33 TCGA studies). These 33 cancers exhibited significant differences in the median AR activity (Kruskal–Wallis test; P < 2.2e−16), with each cancer type displaying a range of activity. Perhaps not surprisingly, because of its androgen dependency, prostate adenocarcinoma (PRAD) has the highest AR activity on average whereas LAML has the lowest (Fig. 1A). This evidence concerns the gene AR and cancer.