AR and prostate adenocarcinoma: Figure 1A depicts the AR activity across all TCGA tumors (10,340 samples in 33 TCGA studies). These 33 cancers exhibited significant differences in the median AR activity (Kruskal–Wallis test; P < 2.2e−16), with each cancer type displaying a range of activity. Perhaps not surprisingly, because of its androgen dependency, prostate adenocarcinoma (PRAD) has the highest AR activity on average whereas LAML has the lowest (Fig. 1A).