AR and cancer: To test this hypothesis, we first investigated the correlation between AR activity and the four prognostic immune signatures (41–44, 56) using six publicly available RNA-seq datasets from pretreatment tumor samples that include response data after ICB treatment from various cancer types [GSE145996 (19), phs000452.v2.p1 (22), GSE135222 (20), GSE126044 (21), Cindy Yang and colleagues (23), and Guan and colleagues (11); Fig. 6].