GLP1R and cholelithiasis: Situations in which special care and attention should be exercised include (but are not limited to) the following: T2DM treated with hypoglycaemic medication (not metformin or GLP-1 drug), T1DM, hypertension treated with antihypertensive medication, cholelithiasis, gallbladder removal, electrolyte deficiency, cardiac arrhythmia, pregnancy, breastfeeding, underweight, intense physical activity, periods of intense stress, and postoperative recovery.