Situations in which special care and attention should be exercised include (but are not limited to) the following: T2DM treated with hypoglycaemic medication (not metformin or GLP-1 drug), T1DM, hypertension treated with antihypertensive medication, cholelithiasis, gallbladder removal, electrolyte deficiency, cardiac arrhythmia, pregnancy, breastfeeding, underweight, intense physical activity, periods of intense stress, and postoperative recovery. This evidence concerns the gene GCG and type 2 diabetes mellitus.