Situations in which special care and attention should be exercised include (but are not limited to) the following: T2DM treated with hypoglycaemic medication (not metformin or GLP-1 drug), T1DM, hypertension treated with antihypertensive medication, cholelithiasis, gallbladder removal, electrolyte deficiency, cardiac arrhythmia, pregnancy, breastfeeding, underweight, intense physical activity, periods of intense stress, and postoperative recovery. Here, GLP1R is linked to chronic obstructive pulmonary disease.