Notably, modulation of ECM composition can reverse cavernoma‐like phenotypes: both thrombospondin‐1 (TSP‐1) and fibronectin (FN) can restore junctional organization in CCM‐deficient endothelial cells (Lopez‐Ramirez et al. 2017; Schwefel, Spiegler, Kirchmaier, et al. 2020). Here, FN1 is linked to cavernous hemangioma.