VEGFA and cavernous hemangioma: A parallel investigation focusing specifically on CASH (cavernous angioma with symptomatic hemorrhage) identified partially overlapping signatures: a diagnostic panel (sCD14–VEGF–CRP–IL‐10) distinguishing recent CASH with 76% sensitivity and 80% specificity, and a prognostic panel—again converging on sCD14, VEGF, IL‐1β, and sROBO4—predicting future hemorrhage with 83% sensitivity and 93% specificity (Lyne et al. 2019).