髓系祖细胞分析[10]:髓系祖细胞是指用CD45/SSC设门CD45dim/SSClow/int的这群细胞。分析CD34+细胞组分至少要分析3×103个CD34+细胞。MDS患者造血祖细胞(Hematopoietic precursor cells,HPC)和MP(CD45dimSSClow/int CD34+ CD19-)均常>2%,ELN iMDS Flow工作组将诊断MDS和MDS/MPN的临界值设定为3%。应同时分析CD45dim SSClow/intCD34+CD19-和CD45dim/SSClow/int这2个细胞群的CD117表达水平,CD117表达增高常提示总生存(OS)差[8]。此外,MP异常表达CD45、CD117、HLA-DR、CD13、CD5、CD7和CD56也已证实与MDS诊断独立相关。. The gene discussed is ANPEP; the disease is myelodysplastic syndrome.