We show that the designer cells could regulate insulin expression to effectively lower blood glucose levels in T1D model mice and induce an anti-obesity therapeutic protein (thymic stromal lymphopoietin, mTSLP) to reduce body weight in HFD mice, when the psicose-containing soft drink (psicose cola) is orally administered. This evidence concerns the gene TSLP and obesity due to melanocortin 4 receptor deficiency.