Specifically, PINK1-mediated mitophagy triggered by urolithin A (UA) promotes the expansion of T memory stem cells (TSCM), ultimately enhancing the efficacy of immunotherapy in colorectal cancer.287 In addition, genetic or pharmacological inhibition of USP30 restores mitophagy, rejuvenates exhausted T cell function, and suppresses tumor growth in murine colon adenocarcinoma.305. This evidence concerns the gene USP30 and neoplasm.