Nuclear BNIP3 in non-small cell lung cancer is associated with poor survival,292 whereas cytoplasmic localization of BNIP3 in breast cancer may suppress malignancy by modulating ROS levels.293 FUNDC1, another hypoxia-induced mitophagy receptor, also plays a dual role in modulating cancer development and progression. The gene discussed is BNIP3; the disease is non-small cell lung carcinoma.