INS and obesity disorder: In HFD-fed mice, UA prevented obesity, liver steatosis, systemic inflammation, glucose intolerance,383 and insulin resistance.378,383 In therapeutic settings, UA also reversed obesity and restored glucose homeostasis.383 Similar anti-obesity effects were observed in the ob/ob genetic mouse models of obesity.383 An ongoing clinical trial (NCT06274749) is investigating whether UA supplementation can improve insulin levels and glucose tolerance in overweight elderly adults.