Parkin is frequently deleted or mutated in cancers such as glioblastoma, breast cancer, colorectal cancer, and ovarian cancer.281–284 Experimental models have revealed that Parkin-knockout mice are highly susceptible to spontaneous hepatocellular carcinoma (HCC).285 Loss of Parkin promotes tumorigenesis by disrupting mitophagy, leading to ROS accumulation, genomic instability, and resistance to apoptosis. This evidence concerns the gene PRKN and hepatocellular carcinoma.