UA alleviated locomotor symptoms in a zebrafish model of ALS that expresses glycine-proline dipeptide repeats in a c9orf72 knockout context.226 In a mouse model of ALS carrying the human SOD1 G93A mutation and exposed to copper, UA activated mitophagy, reduced neuroinflammation, and improved muscle atrophy and motor dysfunction.369 In the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis, UA reduced demyelination and inflammation.370 The potential effects of UA on cognitive function in humans are being investigated (NCT07060898). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.