The small molecule TASIN-1 (truncated APC selective inhibitor-1) selectively induces cytotoxicity in such cells by inhibiting cholesterol biosynthesis.21 Furthermore, elevated cholesterol levels in the inner leaflet of the plasma membrane (IPM) of APC-truncated CRC cells promote Wnt-independent assembly of Wnt signalosomes via interaction with Dishevelled (Dvl). The gene discussed is APC; the disease is colorectal carcinoma.