Hyperactivation of Wnt signaling has been linked to immune suppression through various mechanisms, including TCF/β-catenin-mediated transcriptional activation of PD-L1, which contributes to tumor immune evasion.42,43 However, our study suggests that APC-loss-induced immune evasion in CRC is dependent on PTPN13 but not on the Wnt/β-catenin pathway. Here, PTPN13 is linked to neoplasm.