In addition, we developed a conditional Ptpn13 knockout mouse model (Ptpn13fl/fl), which we crossed with Villin-CreERT2 mice and ApcMin/+ mice (spontaneous tumor mouse model carrying a single mutant Apc allele) to generate ApcMin/+/Ptpn13fl/fl/Vil-CreERT2 (APV) mice (Fig. 2q, r; Supplementary information, Fig. S3s). The gene discussed is VIL1; the disease is neoplasm.