Moreover, in Drosophila models, PARKIN overexpression leads to increased K48-linked polyubiquitination and reduced protein aggregation.458 PARKIN is found at MAMs, where it may facilitate MFN2 ubiquitination and degradation.459 Similarly, leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), a protein linked to PD, localizes to MAMs, where it enhances PERK-mediated phosphorylation of PARKIN, MARCHF5, and mitochondrial E3 ubiquitin ligase activator of NF-κB (MULAN), thereby facilitating the ubiquitination of MFN2.460. This evidence concerns the gene PRKN and Parkinson disease.