TP53 mutation status and unmutated IGHV status are well-established negative prognostic markers.5 Interestingly, the tumor suppressor p53 is known to promote ferroptosis by downregulating xCt expression.27 However, we did not observe a significant impact of TP53 status on ferroptosis sensitivity in CLL. The gene discussed is SLC7A11; the disease is B-cell chronic lymphocytic leukemia.