ACSL4 and B-cell chronic lymphocytic leukemia: Consistent with the observation that ACSL1, but not ACSL4, is more strongly expressed in U-CLL cells than in M-CLL cells, α-ESA treatment led to more pronounced sensitization toward ML162-induced cell death, lipid peroxidation, and Fe2+ depletion in U-CLL cells than in M-CLL cells (Fig. 5f, Supplementary Fig. 6d, e).