GPX4 and B-cell chronic lymphocytic leukemia: In addition, pyruvate, a key glycolytic intermediate, can directly scavenge ROS and thereby mitigate oxidative stress.29 Interestingly, we found that pretreatment with ibrutinib equalized the difference in sensitivity to GPX4 inhibition-induced ferroptosis between U-CLL and M-CLL cells (Fig. 4h).