The key mediators of linoleic acid-driven ferroptosis include acyl-CoA synthetase long-chain family member 1 (ACSL1) and ACSL4.33,34 Interestingly, proteomic data from Meier-Abt et al.30 and Herbst et al.31 confirmed stronger expression of ACSL1, but not ACSL4, in U-CLL cells (Fig. 5d, Supplementary Fig. 6a). Here, ACSL1 is linked to B-cell chronic lymphocytic leukemia.