Another study of metastatic melanoma reported that B. longum, Collinsella aerofaciens, and Enterococcus faecium were highly enriched in responders, and when germ-free mice were reconstituted with feces from these responding patients, the mice showed improved tumor control, heightened T-cell activity, and increased efficacy of anti-PD-L1 therapy [193]. This evidence concerns the gene CD274 and neoplasm.