CD4 and cancer: Similarly, Akkermansia muciniphila has been shown to reinvigorate anti-PD-1 responses after dysbiosis: in antibiotic-treated cancer-bearing mice, supplementation with A. muciniphila restored responsiveness to PD-1 blockade in an interleukin-12-dependent manner, increasing the recruitment of CCR9+CXCR3+CD4+ T lymphocytes into the TME [176].