In vitro and in vivo studies further reveal that CagA mediates epigenetic silencing of tumor suppressive microRNAs, including let-7, miR-26a, and miR-101, through CagA-induced upregulation of c-Myc, DNMT3B, and EZH2, leading to Ras pathway activation [152]. Here, S100A8 is linked to neoplasm.