Palmitoylation of PD-L1 by zinc finger DHHC-type palmitoyltransferase 3 (DHHC3) at C272 has been shown to block PD-L1 mono-ubiquitination, thereby inhibiting ESCRT-mediated multivesicular body sorting and lysosomal degradation in various cancer types [71]. Here, CD274 is linked to cancer.