In the myeloid compartment, TIM-3 restricts the activation of the cGAS-STING pathway in tumor-infiltrating DCs by limiting the uptake of extracellular DNA and by sequestering high-mobility group box 1 (HMGB1), an alarmin that facilitates nucleic acid-mediated innate immune sensing. The gene discussed is HAVCR2; the disease is neoplasm.