SOX2 and acute myeloid leukemia: It enforces stemness maintenance by sustaining redox homeostasis and nucleotide biosynthesis in glioblastoma [32], facilitating ATP-P2X7 signaling in acute myeloid leukemia [67], modulating H3K36me3 epigenetic marks in breast cancer [23], and transcriptionally upregulating pluripotency factors (OCT4, SOX2, KLF4) in thyroid malignancies [63].