Regarding the potential pro-metastatic effects of neutrophils following RT, we observed a significant increase in CD18 expression intensity on neutrophils, a key integrin involved in neutrophil adhesion and cancer cell extravasation, in post-irradiated ectopic xenografts compared to non-irradiated xenografts of both neutrophil-rich MB49 and LLC tumors with post-RT LM (Fig. 3A, B, Fig. S4A-S4C). This evidence concerns the gene ITGB2 and cancer.