Therefore, our major aims were to (1) recapitulate how age and sex modulate Aβ‐related tau accumulation, (2) define age‐ and sex‐stratified amyloid PET thresholds that signal the onset of significant neocortical tau accumulation, and (3) assess whether more advanced amyloid PET–inferred tauopathy stages translate into faster cognitive decline. The gene discussed is MAPT; the disease is tauopathy.