We included 301 ADNI (i.e., 109 CN Aβ–, 97 CN Aβ+, 64 MCI Aβ+, and 31 dementia Aβ+) and 143 A05 (i.e., 41 CN Aβ–, 3 CN Aβ+, 58 MCI Aβ+, and 41 dementia Aβ+) participants with baseline amyloid PET, longitudinal tau PET, and cognitive assessments. Here, MAPT is linked to dementia.