CYP51A1 and fatty liver disease: This finding was confirmed by RT-qPCR, which revealed that XSJ downregulated the expression of cholesterol synthesis genes [42] (e.g., Msmo1, Cyp51, and Sqle) and the metabolism-related gene proprotein convertase subtilisin/kexin type 9 (Pcsk9) [43], leading to improved lipid metabolism and reduced hepatic steatosis.