CD47 and neoplasm: As our previous work demonstrates that the Fc receptor of the macrophage acts as a scaffold for the Fc region of the SRF231 antibody to drive CD47-mediated cell death [18], we further ascertained this non-canonical role of SRF231 in tumor cell death induction by mimicking the antibody scaffolding by hMDM via SRF231 immobilization on protein G-coated plates prior to the addition of primary CLL cells (in the absence of hMDM co-culture).