LDOC1 and non-small cell lung carcinoma: The structural features of LDOC1 suggest that it can interact with nuclear histones, and although it lacks a canonical nuclear localization signal, it predominantly localizes to the nucleus in NSCLC cells; its loss causes broad transcriptomic changes, supporting a role for LDOC1 as an epigenetic regulator acting through histone modifications.<h4>Methods</h4>The levels of histone proteins were assessed in NSCLC cell lines with either LDOC1 knockdown or ectopic expression.