ELISA results revealed that the Aβ1–42 level in the prefrontal cortex of the T1D + TREM2 cKO group was significantly elevated compared to that of the wild-type T1D group (Ctrl vs. T1D: p = 0.0460, T1D vs. T1D + TREM2 cKO: p = 0.0021, Fig. 5q). The gene discussed is TREM2; the disease is type 1 diabetes mellitus.