The normalized analysis revealed that the fluorescence intensity of p-mTOR in individual microglia of wild-type T1D mice remained significantly greater than that in the Ctrl mice (Ctrl vs. T1D: p = 0.0477, Fig. 8i, l), whereas TREM2 knockout significantly reduced the fluorescence intensity (T1D vs. T1D + TREM2-cKO: p = 0.0175, Fig. 8i, l). The gene discussed is MTOR; the disease is type 1 diabetes mellitus.