In T1D mice, the mRNA levels of TREM2, LPL and CST7 in the prefrontal cortex significantly increased at 8 weeks after STZ injection and further increased at 15 weeks (LPL: Ctrl vs. 8 W: p = 0.0266, Ctrl vs. 15 W: p = 0.0171; CST7: Ctrl vs. 8 W: p = 0.0241, Ctrl vs. 15 W: p = 0.0258; TREM2: Ctrl vs. 8 W: p = 0.0211, Ctrl vs. 15 W: p = 0.0029, Fig. 4f). The gene discussed is TREM2; the disease is type 1 diabetes mellitus.