In contrast, TREM2 deletion in T1D mice significantly reduced the number of microglia, increased the 6E10 fluorescence area, and decreased 6E10 expression in microglia (Fig. 5n: Ctrl vs. T1D: p < 0.0001, T1D vs. T1D + TREM2 cKO: p = 0.0249; Fig. 5o Ctrl vs. T1D: p = 0.0004, T1D vs. T1D + TREM2 cKO: p < 0.0001; Fig. 5p: Ctrl vs. T1D: p = 0.0243, T1D vs. T1D + TREM2 cKO: p < 0.0001, Fig. 5m-p). This evidence concerns the gene TREM2 and type 1 diabetes mellitus.