In the prefrontal cortex, the intensity of CD68, a commonly used phagocytic marker, was significantly lower in wild-type T1D mice than in Ctrl mice, and was further reduced in T1D + TREM2 cKO mice (Fig. 7b: Ctrl vs. T1D: p < 0.0001, T1D vs. T1D + TREM2 cKO: p < 0.0001; Fig. 7c: Ctrl vs. T1D: p = 0.0002, T1D vs. T1D + TREM2 cKO: p = 0.0010, Fig. 7a-c). The gene discussed is CD68; the disease is type 1 diabetes mellitus.