Similarly, Western blot results revealed that the expression of Iba1 in the prefrontal cortex of the T1D group significantly increased at 8 weeks, and even more so at 15 weeks (Ctrl vs. 8 W: p = 0.0468, Ctrl vs. 15 W: p = 0.0307 , Fig. 4g, h). Here, AIF1 is linked to type 1 diabetes mellitus.