The fluorescence intensity of p-mTOR in microglia was significantly higher in wild-type T1D mice than in Ctrl mice (Ctrl vs. T1D: p = 0.0142, Fig. 8i, k), but significantly lower in T1D + TREM2 cKO mice than in wild-type T1D mice (T1D vs. T1D + TREM2-cKO: p = 0.0255, Fig. 8i, k). The gene discussed is MTOR; the disease is type 1 diabetes mellitus.