Although the mRNA levels of TREM2, LPL and CST7 in the hippocampus of T1D mice remained unchanged at 8 weeks after STZ injection, a significant increase was observed at 15 weeks, particularly for TREM2 (TREM2: Ctrl vs. 15 W: p = 0.0075, Fig. 4m). The gene discussed is TREM2; the disease is type 1 diabetes mellitus.