TREM2 and type 1 diabetes mellitus: However, compared to the wild-type T1D mice, the T1D + TREM2 cKO mice exhibited a longer latency to locate the platform (Day 8: Ctrl vs. T1D: p < 0.0001, T1D vs. T1D + TREM2 cKO: p = 0.0258, Fig. 5c) and spent less time in the target quadrant (Second quadrant: Ctrl vs. T1D: p = 0.0113, T1D vs. T1D + TREM2 cKO: p = 0.0114, Fig. 5d).