Assessment of tumor infiltrating immune cells (TILs) also has been linked to ICI response in some studies.<h4>Patients and methods</h4>We explored the expression of ARID1A protein using IHC (manual and QuPath) in a cohort of 29 patients with metastatic ccRCC who had undergone cytoreductive nephrectomy (CRN). The gene discussed is ARID1A; the disease is nonpapillary renal cell carcinoma.