CD8A and neoplasm: Acidic conditions directly inhibit TCR signaling pathways, reduce cytokine production and cytotoxicity,206–208 and alter the migratory capacities of T cells, making it more challenging for them to reach and infiltrate tumor sites.209 Furthermore, increased lactate concentrations in the TME inhibit the function of GLUT1, a crucial glucose transporter for CD8+ T cell activation and antitumor immune responses.