ADRB2 and hepatocellular carcinoma: β2-AR signaling has been implicated in sorafenib resistance through the inhibition of HIF-1α autophagic degradation, which subsequently drives glucose metabolic reprogramming in HCC cells.338 Additionally, stress-induced adrenaline has been shown to upregulate ubiquitin-specific protease 10 (USP10) expression, whereby the β2-AR/c-Myc axis stabilizes the pleomorphic adenoma gene-like 2 (PLAGL2) protein, thereby promoting HCC progression.339