STING1 and neoplasm: However, STING activity again diminished postmetastatic colonization.433 On the basis of this mechanism, STING agonists, which are designed to mimic natural ligands such as cyclic GMP-AMP (cGAMP), may force dormant tumor cells to become immunologically exposed, thereby facilitating their destruction by NK cells and T cells.433 This represents a dual strategy: reactivating dormant cells while leveraging innate immunity for their clearance.