HMGB1 and neoplasm: The IL-6/STAT3 signaling pathway, which is abnormally activated during tumor metastasis, has been demonstrated to inhibit immune cell infiltration (including that of CD8+ T cells) and establish premetastatic niches.227 Dying lung tumor cells release DAMPs such as HMGB1 and HSP70, which have been implicated in inflammation-mediated dormancy recurrence.