Additionally, the dissemination of breast cancer cells to the lungs is regulated by type 1 alveolar epithelial cells, which secrete frizzled-related protein 2 (sFRP2), which promotes fibrinogen fibril deposition and integrin-dependent survival signaling, thereby maintaining the dormancy of metastatic breast cancer.138 Similarly, breast cancer cells metastasizing to the brain are governed by astrocytes, which deposit laminin-211, which drives triple-negative breast cancer cell dormancy through inducing the binding of dystroglycan receptors to YAP.7 This evidence concerns the gene SFRP2 and breast cancer.