Multiple studies have shown that the autophagy inhibitor chloroquine can suppress the survival of dormant tumor cells, thereby reducing tumor recurrence and metastasis.28,49 Recent research has indicated that prolonged use of irinotecan induces tumor cells to enter a slow-proliferating, drug-resistant state characterized by downregulation of the Myc and mTOR pathways and upregulation of key autophagy genes. The gene discussed is MYC; the disease is neoplasm.