HMGB1 has been shown to profoundly remodel the immune microenvironment within lung tumors, facilitating immune evasion.188 Following anticancer treatments, the Hsp70-HMGB1 complex released from expired tumor cells has been shown to reactivate neighboring dormant cancer cells.228 Lung cancer-derived exosomes have been shown to suppress antitumor immunity. This evidence concerns the gene HMGB1 and lung cancer.