CDH1 and neoplasm: Following the alleviation of microenvironmental stressors, dormant tumor cells can regain their proliferative capacity via mesenchymal‒epithelial transition (MET) through phenotypic reversion.57,58 More specifically, during early lesion stages, the Wnt-dependent EMT program is activated in tumor cells, resulting in upregulated Twist1 and significantly downregulated E-cadherin expression.